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Investigational compound

Genetics 214 (2), 381395

These findings provide a foundation for further investigations into the peptides impact on major depressive disorder, offering a potential avenue for novel therapeutic strategies

Evidence level: Limited human evidence Sources: PCO-02 safety and pharmacokinetics trial, Intra-articular injection of BPC 157 for multiple types of knee pain How to read this: The registry record has no efficacy result, and the published knee report is retrospective, uncontrolled, and based on telephone follow-up

Mechanistic Overview Extracellular Matrix Signaling GHK-Cu has been studied extensively in models examining collagen synthesis, decorin expression, and glycosaminoglycan production pathways

However, tesofensine did have some side effects related to the gastrointestinal system and increased blood pressure and heart rate